Mediator Release (MRT) Food Sensitivity Testing

Mediator Release (MRT) Food Sensitivity Test - Order Button and Link to Checkout Page The mediator relesae (MRT) food sensitivity test is a type of functional nutrition test which measures the end-point of a food sensitivity reaction – mediator release. 

Out of all the types of food sensitivity tests out there on the market, the MRT test would be my #1 recommendation for those who may be suffering from symptoms of inflammation triggered by food sensitivities!  Read on to learn why, and to determine if MRT food sensitivity testing could be a great next step for you on your journey.

What does “mediator” mean?

In this context, “mediators” are a class of chemicals in the body which are responsible for a variety of inflammatory symptoms often experienced in response to food sensitivities, most generally any of the following:

  • Redness 
  • Itching 
  • Swelling
  • Heat 
  • Pain 

There are many different types of mediators in the body, which are stored and conditionally released into the blood via different types of white blood cells in response to what they believe is a threat.

Examples and types of mediators 

Histamine is one of the most well-known mediators in the human body. 

  • Histamine is the chemical responsible for the inflammatory symptoms that show up in an allergic reaction (itching, redness, swelling, sneezing, constriction, etc.).

Other types of chemical “mediators” responsible for inflammation in a food sensitivity reaction include, but are certainly not limited to:

    • Cytokines
    • Prostaglandins
    • Thromboxanes
    • Leukotrienes
    • Serotonin
    • Bradykinin
    • …And many more!

What is “mediator release”?

Mediator release is a biochemical reaction responsible for the symptoms of both food allergies and food sensitivities (which are two totally separate types of adverse food reactions). White blood cells hold mediators intact (inside the cells) until they’re prompted by a type of protein, called an “immunoglobulin” which signals the white blood cells to release the chemical mediators out into the bloodstream. 

The process of mediator release occurs only when the immune system perceives a particular substance in the blood to be a threat to the body.  

  • In a healthy immune response, mediators are released only during times of illness (such as when our immune system is fighting off a virus or infection).  
  • However, among people with an unhealthy immune response (such as in food allergies, food sensitivities, and/or an autoimmune disorder), particles from certain foods and/or chemicals are mistakenly perceived by the immune system to be an enemy/invader. 

Mediator release in white blood cells - during Food SensitivitiesWhat are food sensitivities?

In food sensitivities, certain particles from food or chemicals get mistakenly flagged as invaders. In response, a variety of white blood cells from all different parts of the body will receive the signal and then release mediators into the blood.

The result is that eating certain foods or chemicals in food will lead to a cascade of unwanted symptoms whether it be a few hours or up to 3-4 days after a reactive food/chemical was consumed.

Symptoms of food sensitivities

The most common symptoms of food sensitivities found to be associated with inflammation caused by mediator release include, but are not limited to:

  • Leaky gut
  • Diarrhea
  • Stomach pain
  • Heartburn/reflux
  • Ulcers
  • Itching
  • Skin breakouts/ rashes
  • Joint pain
  • Muscle pain
  • Headaches/migraines
  • Autoimmune conditions
  • Hormonal imbalance
  • Fluid retention

How do food sensitivities cause inflammation?

Below is a detailed infographic which explains the step-by-step process of mediator release in a food sensitivity reaction.

How food sensitivities cause inflammation, and clinical indicatiors for mrt food sensitivity testing

Where and how to get the MRT food sensitivity test

If you live in the United States, you can order the MRT test through my clinic via the MRT test check-out page HERE or the form below:

Booking Provided by Healthie


MRT Test Frequently Asked Questions

Is MRT a type of allergy test?

Food sensitivities are NOT the same as food allergies, and mediator release testing does not test for allergies! (The gold standard for allergy testing is to get an IgE skin panel at an allergy clinic.)

While both food allergies and food sensitivities involve the immune system, their mechanisms and symptoms in the body are very different.  

  • Allergic reactions take place ONLY in mast cells (a specific type of white blood cell that lives on the mucous membranes of the body – so the gut, skin, lungs and throat).
  • Histamine is the ONLY type of mediator involved in allergic reactions, while food sensitivities can involve any type of mediator.
  • The type of antibody responsible for an allergic reaction (immunoglobulin E, aka “IgE”), is very specific, unlike food sensitivities which involve a broad scope of immunoglobulin pathways.

Food intolerances are another type of adverse food reaction which often get mistaken to be food allergies or sensitivities. 

What makes MRT testing different from other types of food sensitivity tests?

The MRT test is the only version of a food sensitivity test which assesses the full picture of what’s going on. 

It doesn’t just measure ONE pathway in your immune system – it measures the density and volume of your white blood cells before and after getting exposed to each individual food and chemical on the panel.

Who is a good candidate for the MRT food sensitivity test?

In recent years, migraines, joint pain, diarrhea-predominant irritable bowel syndrome (IBS-D), inflammatory bowel diseases (IBD), and certain types of autoimmune disorders are found to correlate with mediator release and food sensitivities.

If you’re experiencing any of the following, the MRT test could be very informative and enlightening for you:

  • Diarrhea-predominant IBS
  • Crohn’s disease
  • Ulcerative Colitis
  • Celiac disease
  • Gastritis
  • Peptic ulcers
  • Heartburn/reflux
  • Urticaria (hives)
  • Acne
  • Psoriasis
  • Eczema
  • Polycystic ovarian syndrome (PCOS)
  • Fibromyalgia
  • Arthritis
  • Hashimoto’s (autoimmune hypothyroid)
  • Grave’s disease (autoimmune hyperthyroid)
  • Lupus
  • Mast cell activation syndrome (MCAS)
  • PANDAS syndrome
  • Migraines
  • Headaches
  • Lymphedema
  • Chronic fatigue
  • Major depressive disorder (MDD)
  • Anxiety disorder
  • Autism spectrum disorder (ASD)
  • Schizophrenia
  • Epilepsy
  • And more!

Who is NOT a good candidate for MRT?

While food sensitivity reactions can lead to lots of different unwanted symptoms, it’s important to note that MRT testing is not for everyone!

I would not recommend getting the MRT test if there’s a tendency towards disordered eating or an unhealthy relationship with food.  

  • Food sensitivity testing (even with the best of intentions) comes with the potential to trigger behaviors of dietary restriction, anorexia, orthorexia, binging, and/or bulimia among people with eating disorders.

I also wouldn’t recommend pursuing MRT if you aren’t ready to commit to yourself and take the time to do things like food logging and meal planning/prepping.

  • (Throwing money at problems is not enough to make them go away – you’ve still gotta do the work!) 😉 

MRT testing is also not going to be as helpful or relevant for people experiencing conditions that are NOT directly linked with mediator release/food sensitivities, such as:

  • Constipation without diarrhea
  • Gas 
  • Bloating
  • Conditions caused by physical trauma/injury 
  • Acute illnesses/infections

Which foods and chemicals are tested?

How much does MRT testing cost?

  • The retail price for the full panel of 176 different foods and chemicals is $695. 
    • Some practitioners may charge more, and others may bundle this test into a full program for a reduced rate on the test itself.  
      • When you work with a certified LEAP therapist, you’ll usually also have the opportunity to receive custom meal planning services (which require LOTS of time and for us on the back-end but will be VERY helpful for you). This is a common reason why some practitioners charge more than the retail price listed, and it’s still well worth the investment!

Is the mediator release test covered by insurance?

  • Unfortunately MRT testing is not covered by any insurance plan. 
    • However, you may use a FSA/HSA card to pay for this test and you can also use those types of cards to cover any blood draw fees associated with MRT.

Why is MRT more expensive than other food sensitivity tests?

  • MRT food sensitivity testing paired with lifestyle eating and performance (LEAP) therapy is the gold standard for addressing food sensitivities.  This approach will give you the full picture of what you need to know and implement so you’re unraveling and resolving imbalances holistically – at the cellular level. 
    • Other tests are only showing you a sliver or slice of the pie! They only measure individual pathways which are a fraction of the full picture of mediator release.

WIll I have to avoid the “reactive” foods and chemicals on my MRT panel forever?

  • Not necessarily!  It’s generally recommended that you re-introduce and re-test the foods that showed up to be moderately reactive (in the yellow) after ~3 months, and that youo re-test the foods that show up to be highly reactive (in the red) after at least ~6 months, so you can ideally re-establish your “oral tolerance” to these foods.  
    • Whether or not you can resume eating these foods will depend on how your body responds and how you’re feeling!

Will MRT and LEAP therapy provide me with everything I need to heal and recover 100%?

  • While these interventions are extremely powerful (and can often lead to people feeling up to 50-90% better in a matter of weeks), MRT and LEAP are not enough as a stand-alone intervention to serve as a “be-all end-all” cure to your chronic health condition.  
    • LEAP and MRT are meant to complement and enhance your journey, alongside other interventions whether they be medical or nutritional (or both).
  • Given that food sensitivities typically go hand-in-hand with dysbiosis and leaky gut, the MRT + LEAP approach is most effective when paired with GI mapping.

How to get the MRT food sensitivity test:

While simply running the MRT test and getting results to satisfy curiosity is all most people want, stopping there is not enough to help you from a “best practice” standpoint.  Navigating food sensitivities can get confusing and overwhelming, very quickly!

You can order this test through my functional nutrition clinic, HERE.

  • My 1:1 practice is currently full, so I won’t be able to guide you through the LEAP diet protocol 1:1.  While you may access my complimentary tutorials to help you understand your results, it will also be very helpful for you to consult with another certified Lifestyle Eating and Performance (LEAP) therapist who licensed in your state (see below) to get additional support on this path.

Work with a certified LEAP therapist

I highly recommend embarking on your MRT journey alongside a certified LEAP therapist, so that you’re supported and equipped with the proper guidance and clinical nutrition supervision along the way.

  • A certified LEAP therapist (CLT) is a type of functional dietitian-nutritionist who has received specialty training in the immune system, adverse food reactions, and mediator release testing.  
    • Our mission is to help you to fully interpret and understand your test results, co-design a custom eating plan that helps you make quantum “leaps” on your journey (pun intended), and set you up for long-term success!
  • A CLT will use clinical discernment to help you determine whether MRT food sensitivity testing is appropriate for you or not.

The LEAP Immunocalm diet protocol

CLT’s are also trained to guide and coach clients through an optional 6-part LEAP “Immunocalm Diet” (also referred to as an “oligo-antigenic” plan), which is essentially a customized eating plan we’ll co-create together to incorporate all of your body’s BEST foods in a nutritionally sound way.  

  • The Immunocalm eating plan is something we design and craft together based on your food preferences, eating patterns, goals, and MRT test results.

When properly followed, in my clinic I’ve observed the Immunocalm approach can lead to 50-90% improvement (from a symptom reduction standpoint) within the first few weeks!

If you’re interested in working together on your journey, I’d love to support you!  Below is a step-by-step outline of how you can obtain the MRT test through working with me.

MRT and LEAP with a Certified LEAP Therapist: step-by-step

  1. Optional but recommend:  if you’re unsure whether the MRT food sensitivity test will help you or not, you can consult a LEAP therapist to make sure MRT is a good fit based on your unique clinical picture and nutrition/health goals.
  2. When you purhcase the MRT test (through here or via another functional nutrition clinic), you’ll then be prompted to complete an intake form with pertinent information such as your name, date of birth, email, phone number, a mailing address (for the test kit to be shipped to), your health goals and reason for wanting the MRT test, and a list of supplements & medications you’re currently taking.
  3. You’ll then receive a special MRT test requisition form (via secure document sharing in my client portal or from your practitioner), along with a PDF of instructions on next steps.
  4. You’ll receive a MRT test kit in the mail, delivered to your address on file, within the next few business days.
  5. The next step is to book a blood draw with a local lab in network with Oxford Biomedical Technologies (the company through which you’ll receive the Mediator Release test kit and results booklet).
    1. Your appointment should be on a Monday, Tuesday, Wednesday, or Thursday after 12 noon – since the samples are time-sensitive, and samples that sit over a weekend before getting processed by the lab can result in less accurate results.
    2. Make sure to bring the requisition form and MRT test kit to your blood draw appointment!
  6. Once your blood draw is all set, and the samples have been submitted, the level of reactivity (degree of mediator release) occurring within your white blood cells from the sample collections will be measured against a control as well as 176 different foods and chemicals.
  7. Within less than 1 week of your blood draw, my clinic (or the clinic through which you ordered this test) will receive a secure PDF with your results. You’ll also receive a hard copy of your results within a 50+ page booklet for you to refer to so you can learn more about how to navigate food sensitivities and possible dietary restrictions through restaurant planning and recipe modification.  (If you choose to order this test via my clinic, you’ll also get lifetime access to a bonus course on how to navigate your MRT food sensitivity test results!)
  8. Before making any dietary changes you’ll be prompted to complete a baseline symptom survey, which you’ll be able to look back on down the road to assess your progress!
  9. You will want to schedule a 1:1 appointment with a certified LEAP therapaist to go over your results. Your LEAP therapist will walk you through a nutritional assesment and help you to determine next steps and possibly co-create your custom LEAP eating plan.  This can occur in phases, or your LEAP therapist can also help you to modify your treatment plan to meet you where you’re at.
  10. You’ll begin implementing the LEAP eating plan or next steps recommended by your LEAP therapist.  You will be instructed and encouraged to keep a detailed food-symptom journal so you and your LEAP therapist can get as much feedback as possible about what’s working and what isn’t!
  11. You and your LEAP therapist will follow up weekly or as needed, over the coming months, depending on the amount of support you need along the way.

MRT Test - Blood Draw Specimen Collection and Shipping ProcessMRT testing – next steps

  1. Consult with a certified LEAP therapist to make sure you’re a great candidate for the MRT test (search to find a LEAP therapist near you)
  2. Order your MRT test to uncover which foods are triggering your diet-induced inflammation
  3. Stay tuned for prompts to complete intake forms, receive updates on your test kit shipment, sample collection, blood draw appointment, and test results.
  4. If you order this test through my clinic, stay tuned for updates on complimentary BONUS access to my upcoming MRT online course which is in the works, so you can feel more informed and empowered on this journey!
  5. Consider working 1-1 with a LEAP therapist to determine your best next steps based on where you’re at and what your results reveal.

More resources

If this stuff is calling your name, and you’d like to learn more about what I have to say on all things leaky gut, MRT, food sensitivities and beyond, make sure to check out the following articles and resources: