Food Allergies vs. Intolerances vs. Sensitivities – How are they Different?
Food allergies, intolerances, and sensitivities – oh my! Another topic near and dear to my heart.
Yup, they’re three totally different “things”… and yes, it’s entirely possible to experience all three types of adverse food reactions day-to-day.
Dietary restrictions: the struggle is real!
There’s nothing worse than walking into a restaurant, looking at a menu and trying to find SOMETHING (anything) you can eat that won’t send you spiraling into some kind of inflammatory reaction.
At the same time, for those dealing with frequent heartburn, spontaneous hives, stomach pain, IBS, gas, bloating, brain fog, skin eruptions, joint pain, etc.… I think it’s safe to say it’s better to know exactly what it is that the body is reacting to, than to not know. In any of those cases, ignorance is definitely NOT bliss!
Adverse food reactions – key differences
It’s important to know and understand the key differences in these various types of adverse food reactions, because each of them can have a very different kind of impact on health, quality of life, and recommended treatment protocols. It’s tricky because there can sometimes be a lot of overlap in types of symptoms!
Types of reactions
A main difference among food allergies, intolerances and sensitivities is that food intolerances are only related to the digestive system, while food allergies and sensitivities both involve the immune system (in different ways).
Food allergies are a specific type of immune response in which the immune system has flagged something we’ve eaten as a falsely perceived threat to the body.
- This is more likely to happen in cases of leaky gut, where undigested food particles sneak (or “leak”) into the bloodstream through a damaged gut lining.
In cases of food allergies, our immune system produces a type of antibody called “immunoglobulin E”, or “IgE” for short, in reaction to the first exposure to a specific food. The second time we eat that food, these IgE antibodies circulate the body and attach themselves to mast cells (tissue-specific white blood cells which line the mucous membranes of the body).
An allergic reaction to a food can only take place in the mucous membranes of the body where these mast cells are located. This includes the gut (for example: sudden onset diarrhea), the throat (swelling/closing up), the skin (acute onset itching and hives), the lungs (trouble breathing) and/or the mouth (itching and tingling).
Allergic reactions can be mild and localized (such as in cases of “oral allergy syndrome”). or life-threatening and systemic (anaphylaxis, which requires an “epi-pen” to prevent the body from going into shock from too-low blood pressure or trouble breathing).
Food intolerances will show up as digestive symptoms such as gas, abdominal cramping, bloating, and/or diarrhea. Food intolerances don’t involve the immune system at all; they’re caused by a lack of specific types of digestive enzymes and/or the presence or absence of specific microbes in the gut.
For example, in cases of lactose intolerance, a person is typically missing or low in the digestive enzyme “lactase” which is responsible for breaking down lactose (natural sugar from milk) in the gut.
- Based on case study and anecdotal observations, people who are low in certain microbes (such as acidophilus or lactobacillus) can also have trouble breaking down lactose!
If you’re truly lactose intolerant and don’t have a dairy allergy or sensitivity, you should be able to eat “hard cheeses” such as cheddar, Swiss, Havarti or the likes (they all have zero grams of sugar, therefore are naturally “lactose free”) and yogurt (which has acidophilus or lactobacillus to help break down the lactose). People with lactose intolerance tend to have the most trouble with milk and ice cream but can eat butter, ghee, and many types of cheese (and pizza too!) without any issues.
- If you find that you can’t eat pizza, butter, ghee, you should consider getting allergy tested and/or food sensitivity tested to rule out a dairy allergy/sensitivity!
Another example of a food intolerance is fructose.
Fructose is found in all fruits, juices, honey, agave nectar, high fructose corn syrup (go figure), and many other foods!
Fructose intolerance is common among people who have a digestive condition called “small intestinal bacterial overgrowth” (SIBO) because it’s in the category of “fermentable oligosaccharides, disaccharides, monosaccharides and polyols” (high FODMAP foods).
- Don’t go on a low FODMAP diet without first ruling out SIBO and getting medically treated if you do have it! I explain more about why in my free nutrition guide for gut health (here or below).
Food sensitivities are the most confusing and the most complex for people to understand. They’re often mistakenly labeled as “allergies” or “intolerances”… but as you now know, that is not the case! It’s understandable though because diarrhea. a primary symptom of food intolerances, can also be caused by food sensitivities (and sometimes allergies too).
Like food allergies, food sensitivities also involve the immune system; however, the response is not specific to IgE antibodies, and a food sensitivity reaction is not limited to the mast cells located within the mucous membranes of the body.
In a nutshell, food sensitivities are any and all types of immune-mediated reactions that don’t involve IgE. There are other categories of antibodies that can be involved, and many types of mediators which can be released from various types of white blood cells that make up our immune system.
Symptoms of a food sensitivity can be very delayed (up to 96 hours after eating a food!), and they can also be dose-dependent (so for example we can react after exceeding certain thresholds of foods). This makes food sensitivities the most difficult to navigate and identify.
Since food sensitivities involve different types of mediators aside from just histamine, food sensitivity reactions can manifest very differently from person to person depending on where in the body they are taking place.
It’s possible you may have an underlying food sensitivity (and probably leaky gut, too) if you’re experiencing any of the following:
- Diarrhea-Predominant Irritable Bowel Syndrome
- Eosinophilic Esophagitis
- Crohn’s Disease
- Cyclic Vomiting Syndrome
- Interstitial Cystitis
- Autism Spectrum Disorders
- Restless Leg Syndrome
- Polycystic Ovarian Syndrome (PCOS)
- Mysterious skin eruptions
- Unexplainable fluid retention
- Urticaria (hives)
Although the above conditions are usually linked to other clinical implications, it’s important to rule out and address food sensitivities along the way. I believe in un-turning as many stones as possible until people are able to get to the underlying root causes of a condition from all angles! Things always happen for a reason. Whether it’s nutrition-related or energetic, gut-related, genetic, stress-related or something else.
Many health issues can be resolved 90% of the time in my experience if you just keep going. All roads lead to Rome! 😉
Timing of adverse food reactions
An IgE food allergy is going to occur typically within minutes, or at most within the hour.
Food intolerances are most likely to occur within 30 minutes to a few hours’ time, depending on how quickly the transit time varies from person to person.
Food sensitivities are the most difficult to identify through food-symptom journals alone because we can have a reaction up to 96 hours after consumption of the food. Yikes! This is why I include food sensitivity testing in my VIP program for people with specific types of conditions that don’t seem to respond to any kind of cookie-cutter approach (whether traditional or alternative).
Testing for adverse food reactions
Food allergy testing
The best way to rule out food allergies (aside from “oral challenge tests” which can be very scary and traumatizing for people with severe reactions) is to get a skin test and blood test from a doctor at a local allergy clinic.
Gluten allergies can be measured by ruling out celiac disease via a blood test or intestinal biopsy. A gluten allergy (celiac disease) is different from a gluten intolerance or sensitivity.
- Cutting out gluten via an elimination diet is not always the best way to rule out a gluten allergy/sensitivity/intolerance – you can learn why here in my free gut health nutrition guide!
To rule out a lactose intolerance, typically patients at a doctor’s office will be asked to drink an unpleasant amount of milk and they track your symptoms within the next 30 minutes… Most people opt to go by their clear symptoms caused by drinking milk, and avoid this fun test. 😉
A fructose intolerance can be ruled out via a breath test, but it’s best to consult a GI doctor first because a fructose intolerance may be accompanied by other underlying conditions such as SIBO or dysbiosis.
Food-symptom journals, although subjective, can also be helpful in identifying any potential food intolerances (especially when dealing with other types of foods or chemicals in food such as histamine). It’s possible to react to anything.
- In my opinion, this process of identifying food intolerances through a food-symptom is best done working 1:1 with a registered dietitian who specializes in digestive health, leaky gut and adverse food reactions. (I know, I know… consider the source! But honestly it will save you years of guessing and spare you a whole lot of frustration/confusion/discomfort.)
Food sensitivity testing
If you’d like to rule out food sensitivities, first you should make sure you’re a good candidate! Are you presenting with a bunch of the above symptoms and not responding to conventional medical approaches/cookie cutter diets? (If so, you’re not alone… and this may be very helpful for you!)
The Mediator Release Test (MRT Test)
My preferred method of food sensitivity testing is the Mediator Release Test (MRT), which includes a customized six-part “oligoantigenic” Lifestyle Eating & Performance (LEAP) diet based on YOUR specific test results. Why spend months or years trying to do guess-work when we don’t have to?!
You must first get screened by a registered dietitian who can offer Mediator Release Testing before embarking on that journey.
- Note: Of course I would also screen someone for an eating disorder before recommending this approach (since the diet is highly restrictive in the beginning). So it’s not for everyone even if you do have many different types of inflammatory symptoms- you must also have a healthy relationship with food.
The MRT food sensitivity test (paired with the LEAP diet) are my favorite because they’re the most holistic and the most customized approach for addressing food sensitivities. MRT testing measures the body’s reactions from an entire standpoint – it doesn’t just look at certain types of pathways (IgG, IgA, IgE) or certain types of mediators (like histamine); it measures the change in white blood cells’ solid to liquid ratio before and after being exposed to each food and chemical on the panel. This is like walking around and looking at the entire statue as a whole versus just looking at it from the front or the back!
- FYI – MRT for food sensitivities is a key component I include as one of of the 6 pillars of my new 6-month Gut Repair 1:1 program (for those who meet all the criteria)!
Is it possible to get rid of food allergies, intolerances or sensitivities naturally?
In many cases, yes!
- The immune system resides primarily in the gut, so if you can repair your leaky gut while supporting your liver, reducing stress and addressing all the other aspects of health impacting your immune system (where allergies reside), you can promote healing and re-balancing of your immune system!
I’ve personally been on a journey of reversing my Oral Allergy Syndrome (caused by leaky gut) since 2013-2014, and my most recent food allergy skin test was literally yesterday (April 27, 2021). As of yesterday I’ve “gained back” almost 20 foods since I started! Kind of a big deal. That is my definition of food freedom!
It’s a slow process and for the long game (no instant gratification)… But living a holistic lifestyle long-term that promotes healing is something I’ll continue to practice, and something I’ll continue to teach those who work with me!
Thanks for reading, and stay tuned for future updates!
Disclaimer: This is not medical advice! This article is meant to be educational, informative and inspiring. Make sure to consult GI doctors, allergists, registered dietitians and other qualified health practitioners to address your health concerns from a medical nutrition standpoint!